Research in the Cusumano Group
Selectivity on Flat Potential Energy Surfaces
Achieving selectivity from fleeting intermediates that exist on flat regions of a potential energy surface (PES) presents a unique challenge for rational reaction design. Understanding selectivity in these systems requires looking beyond the PES’s critical points (i.e., transition structures) and considering molecular motion, energy distribution, and solvent structure. Our group aims to not only better understand the factors governing selectivity in such reactions, but also to develop tools and strategies to control the reactivity of fleeting intermediates.
Asymmetric Catalysis
First row transition metals are an exciting platform from which to explore electronic structure-reactivity relationships relevant to catalysis. Our group aims to develop new first-row transition metal-catalyzed asymmetric transformations, particularly those featuring diradical intermediates and high energy intermediates.
Main Group Photochemistry
Our research focuses on developing strategies that leverage the energy of light to promote bond activations and formations that are otherwise difficult to achieve. A central aspect of our work is the rational design and control of excited-state electronic mechanisms.
Computational Chemistry
Computational chemistry is central to our research endeavors. Our group utilizes diverse computational methods to guide reaction design, test mechanistic hypotheses, and gain molecular-level insights. Together with experiment, it enables us to explore chemical systems in unparalleled detail.